[13] Willem II 1-3 Cambuur Leeuwarden [7] 2021-12-10 19:00
Stadion: König-Wilhelm-II.-Stadion Round: 16
Schiedsrichter: Martin Van den Kerkhof Home Manager: Fred Grim Away Manager: Henk De Jong
Head to Head
| Niederlande - Eredivisie | 2016/04/21 16:30 | Cambuur Leeuwarden v Willem II | D | 1-1 |
| Niederlande - Eredivisie | 2015/12/06 11:30 | Willem II v Cambuur Leeuwarden | W | 3-0 |
| Niederlande - Eredivisie | 2015/05/17 12:30 | Cambuur Leeuwarden v Willem II | W | 1-2 |
| Niederlande - Eredivisie | 2014/11/02 13:30 | Willem II v Cambuur Leeuwarden | D | 1-1 |
Home History
| Niederlande - Eredivisie | 2021/12/02 20:00 | Ajax v Willem II | L | 5-0 |
| Niederlande - Eredivisie | 2021/11/27 20:00 | Willem II v Go Ahead Eagles | L | 0-1 |
| Niederlande - Eredivisie | 2021/11/21 13:30 | Heerenveen v Willem II | L | 2-1 |
| Niederlande - Eredivisie | 2021/11/06 19:00 | Willem II v Sparta Rotterdam | L | 0-3 |
| Niederlande - Eredivisie | 2021/10/31 15:45 | FC Utrecht v Willem II | L | 5-1 |
| Niederlande - Pokal | 2021/10/28 19:00 | RKC v Willem II | L | 3-0 |
| Niederlande - Eredivisie | 2021/10/22 18:00 | Willem II v Fortuna Sittard | D | 1-1 |
| Niederlande - Eredivisie | 2021/10/17 14:45 | FC Twente v Willem II | D | 1-1 |
Away History
| Niederlande - Eredivisie | 2021/12/04 17:45 | Cambuur Leeuwarden v Vitesse | L | 1-6 |
| Niederlande - Eredivisie | 2021/11/26 19:00 | NEC v Cambuur Leeuwarden | W | 2-3 |
| Niederlande - Eredivisie | 2021/11/21 19:00 | Cambuur Leeuwarden v FC Utrecht | W | 2-1 |
| Niederlande - Eredivisie | 2021/11/06 20:00 | PEC Zwolle v Cambuur Leeuwarden | W | 1-2 |
| Niederlande - Eredivisie | 2021/10/31 15:45 | RKC v Cambuur Leeuwarden | W | 0-1 |
| Niederlande - Pokal | 2021/10/28 16:45 | Ajax Amateurs v Cambuur Leeuwarden | W | 0-5 |
| Niederlande - Eredivisie | 2021/10/24 12:30 | Cambuur Leeuwarden v Feyenoord Rotterdam | L | 2-3 |
| Niederlande - Eredivisie | 2021/10/16 19:00 | Fortuna Sittard v Cambuur Leeuwarden | L | 1-0 |