[4] Spartak Moskau 2-1 Neapel [1] 2021-11-24 15:30
Stadion: Otkrytije Arena Round: 5
Schiedsrichter: Clement Turpin Home Manager: Rui Vitoria Away Manager: Luciano Spalletti
Head to Head
| UEFA Europa League | 2021/09/30 16:45 | Neapel v Spartak Moskau | W | 2-3 |
Home History
| Russland - Premier League | 2021/11/20 16:00 | Krasnodar v Spartak Moskau | L | 2-1 |
| Russland - Premier League | 2021/11/07 16:00 | Spartak Moskau v Lokomotive Moskau | D | 1-1 |
| UEFA Europa League | 2021/11/04 20:00 | Leicester v Spartak Moskau | D | 1-1 |
| Russland - Premier League | 2021/10/30 13:30 | Spartak Moskau v Rostow | D | 1-1 |
| Russland - Premier League | 2021/10/24 16:00 | Zenit St Petersburg v Spartak Moskau | L | 7-1 |
| UEFA Europa League | 2021/10/20 14:30 | Spartak Moskau v Leicester | L | 3-4 |
| Russland - Premier League | 2021/10/16 16:00 | Spartak Moskau v Dynamo Moskau | D | 2-2 |
| Russland - Premier League | 2021/10/03 16:00 | FC Akhmat Grozny v Spartak Moskau | W | 0-1 |
Away History
| Italien - Serie A | 2021/11/21 17:00 | Inter Mailand v Neapel | L | 3-2 |
| Italien - Serie A | 2021/11/07 17:00 | Neapel v Verona | D | 1-1 |
| UEFA Europa League | 2021/11/04 17:45 | Legia Warschau v Neapel | W | 1-4 |
| Italien - Serie A | 2021/10/31 17:00 | Salernitana v Neapel | W | 0-1 |
| Italien - Serie A | 2021/10/28 18:45 | Neapel v Bologna | W | 3-0 |
| Italien - Serie A | 2021/10/24 16:00 | AS Rom v Neapel | D | 0-0 |
| UEFA Europa League | 2021/10/21 19:00 | Neapel v Legia Warschau | W | 3-0 |
| Italien - Serie A | 2021/10/17 16:00 | Neapel v Turin | W | 1-0 |