[4] Lazio Rom 2-0 Lokomotive Moskau [3] 2021-09-30 19:00
Stadion: Olympiastadion Rom Round: 2
Schiedsrichter: Craig Pawson Home Manager: Maurizio Sarri Away Manager: Marko Nikolic
Home History
| Italien - Serie A | 2021/09/26 16:00 | Lazio Rom v AS Rom | W | 3-2 |
| Italien - Serie A | 2021/09/23 16:30 | Turin v Lazio Rom | D | 1-1 |
| Italien - Serie A | 2021/09/19 16:00 | Lazio Rom v Cagliari | D | 2-2 |
| UEFA Europa League | 2021/09/16 16:45 | Galatasaray Istanbul v Lazio Rom | L | 1-0 |
| Italien - Serie A | 2021/09/12 16:00 | AC Mailand v Lazio Rom | L | 2-0 |
| Italien - Serie A | 2021/08/28 16:30 | Lazio Rom v Spezia | W | 6-1 |
| Italien - Serie A | 2021/08/21 18:45 | Empoli v Lazio Rom | W | 1-3 |
| Freundschaftsspiele - Europa | 2021/08/14 17:00 | Lazio Rom v Sassuolo | D | 1-1 |
Away History
| Russland - Premier League | 2021/09/25 11:00 | FK Khimki v Lokomotive Moskau | D | 0-0 |
| Russland - Premier League | 2021/09/20 13:30 | Ural v Lokomotive Moskau | D | 0-0 |
| UEFA Europa League | 2021/09/16 16:45 | Lokomotive Moskau v Marseille | D | 1-1 |
| Russland - Premier League | 2021/09/11 11:00 | Lokomotive Moskau v Krylia Sovetov | W | 2-0 |
| Freundschaftsspiele - Europa | 2021/09/05 14:00 | ZSKA Moskau v Lokomotive Moskau | W | 1-2 |
| Russland - Premier League | 2021/08/27 16:00 | Dynamo Moskau v Lokomotive Moskau | D | 1-1 |
| Russland - Premier League | 2021/08/22 13:00 | Lokomotive Moskau v Krasnodar | W | 2-1 |
| Russland - Premier League | 2021/08/15 14:30 | Lokomotive Moskau v Zenit St Petersburg | D | 1-1 |