Stadion: Pioneer Field Round: 1
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | W | 37-21 |
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 38-31 |
| NCAAF | 2021/10/02 22:00 | Wingate Bulldogs v Tusculum Pioneers | L | 43-35 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | L | 19-24 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | W | 24-21 |
| NCAAF | 2021/09/11 17:00 | Tusculum Pioneers v Chowan Hawks | L | 38-46 |
| NCAAF | 2021/09/04 17:00 | St Augustines Falcons v Tusculum Pioneers | W | 14-58 |
| NCAAF | 2019/11/16 18:00 | Carson–Newman Eagles v Tusculum Pioneers | L | 49-13 |
| NCAAF | 2021/10/16 22:00 | Barton Bulldogs v Wingate Bulldogs | W | 26-20 |
| NCAAF | 2021/10/09 17:30 | Mars Hill Lions v Barton Bulldogs | L | 40-32 |
| NCAAF | 2021/10/02 18:00 | Barton Bulldogs v Carson–Newman Eagles | W | 31-17 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | W | 7-45 |
| NCAAF | 2021/09/18 17:00 | Catawba Indians v Barton Bulldogs | L | 17-10 |
| NCAAF | 2021/09/11 17:00 | Erskine Flying Fleet v Barton Bulldogs | W | 21-45 |
| NCAAF | 2021/09/04 18:00 | Barton Bulldogs v Newberry Wolves | L | 7-31 |