Stadion: Villanova Stadium Round: 1
Home Manager: Mark Ferrante Away Manager: Bob Chesney
| NCAAF | 2021/11/27 17:00 | Sacred Heart v Holy Cross | W | 10-13 |
| NCAAF | 2021/11/20 18:00 | Holy Cross v Bucknell | W | 45-6 |
| NCAAF | 2021/11/13 18:00 | Holy Cross v Fordham | W | 52-24 |
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | W | 10-35 |
| NCAAF | 2021/10/30 16:00 | Holy Cross v Lehigh | W | 31-12 |
| NCAAF | 2021/10/23 21:00 | Colgate v Holy Cross | W | 10-42 |
| NCAAF | 2021/10/16 17:30 | Georgetown v Holy Cross | W | 14-48 |
| NCAAF | 2021/10/02 17:30 | Harvard v Holy Cross | L | 38-13 |
| NCAAF | 2021/11/20 18:00 | Villanova v Delaware | W | 21-13 |
| NCAAF | 2021/11/13 18:00 | Stony Brook v Villanova | W | 14-33 |
| NCAAF | 2021/11/06 18:00 | Villanova v Elon | W | 35-0 |
| NCAAF | 2021/10/30 17:00 | William & Mary v Villanova | L | 31-18 |
| NCAAF | 2021/10/23 19:30 | Rhode Island v Villanova | W | 0-44 |
| NCAAF | 2021/10/16 19:30 | Villanova v Albany | W | 17-10 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | W | 28-27 |
| NCAAF | 2021/09/25 16:00 | Villanova v Penn State | L | 17-38 |