Stadion: Ernest W. Spangler Stadium Round: 1
Home Manager: Tre Lamb Away Manager:
| NCAAF | 2021/11/20 18:00 | Gardner Webb v North Carolina A&T | W | 35-27 |
| NCAAF | 2021/11/13 18:30 | Charleston Southern v Gardner Webb | L | 32-24 |
| NCAAF | 2021/11/06 17:00 | Gardner Webb v Hampton | L | 21-27 |
| NCAAF | 2021/10/30 17:00 | Gardner Webb v Kennesaw State | L | 30-34 |
| NCAAF | 2021/10/23 17:30 | Robert Morris v Gardner Webb | W | 17-28 |
| NCAAF | 2021/10/09 22:00 | Campbell v Gardner Webb | L | 42-28 |
| NCAAF | 2021/10/02 17:00 | Gardner Webb v Monmouth | L | 17-54 |
| NCAAF | 2021/09/25 22:00 | Western Carolina v Gardner Webb | W | 34-52 |
| NCAAF | 2021/11/13 21:00 | Limestone Saints v Newberry Wolves | L | 7-42 |
| NCAAF | 2021/11/06 17:00 | Carson–Newman Eagles v Limestone Saints | L | 27-21 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 24-28 |
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | L | 45-3 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | L | 3-32 |
| NCAAF | 2021/10/09 17:00 | Limestone Saints v Wingate Bulldogs | L | 17-35 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | L | 7-45 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | L | 24-21 |