Stadion: Fitton Field Round: 1
Home Manager: Bob Chesney Away Manager: Tony Reno
| NCAAF | 2021/09/18 16:00 | Holy Cross v Yale | L | 20-17 |
| NCAAF | 2019/09/21 17:00 | Holy Cross v Yale | W | 10-23 |
| NCAAF | 2018/09/15 17:05 | Yale v Holy Cross | L | 28-31 |
| NCAAF | 2017/10/14 17:00 | Yale v Holy Cross | W | 32-0 |
| NCAAF | 2021/11/20 17:00 | Harvard v Yale | L | 34-31 |
| NCAAF | 2021/11/13 18:00 | Yale v Princeton | L | 20-35 |
| NCAAF | 2021/11/06 16:30 | Yale v Brown | W | 63-38 |
| NCAAF | 2021/10/30 16:00 | Columbia v Yale | W | 30-37 |
| NCAAF | 2021/10/23 16:00 | Pennsylvania v Yale | W | 28-42 |
| NCAAF | 2021/10/16 16:00 | Yale v Connecticut | L | 15-21 |
| NCAAF | 2021/10/09 17:30 | Yale v Dartmouth | L | 17-24 |
| NCAAF | 2021/10/02 16:00 | Yale v Lehigh | W | 34-0 |
| NCAAF | 2022/09/10 22:00 | Holy Cross v Buffalo | W | 37-31 |
| NCAAF | 2022/09/02 23:00 | Holy Cross v Merrimack | W | 31-17 |
| NCAAF | 2021/12/04 00:00 | Holy Cross v Villanova | L | 16-21 |
| NCAAF | 2021/11/27 17:00 | Sacred Heart v Holy Cross | W | 10-13 |
| NCAAF | 2021/11/20 18:00 | Holy Cross v Bucknell | W | 45-6 |
| NCAAF | 2021/11/13 18:00 | Holy Cross v Fordham | W | 52-24 |
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | W | 10-35 |
| NCAAF | 2021/10/30 16:00 | Holy Cross v Lehigh | W | 31-12 |