Stadion: Harvard Stadium Round: 1
Home Manager: Tim Murphy Away Manager: Bob Chesney
| NCAAF | 2021/10/02 17:30 | Harvard v Holy Cross | L | 38-13 |
| NCAAF | 2019/10/19 17:00 | Harvard v Holy Cross | L | 31-21 |
| NCAAF | 2018/10/12 23:00 | Harvard v Holy Cross | L | 33-31 |
| NCAAF | 2022/09/24 17:00 | Holy Cross v Colgate | W | 35-10 |
| NCAAF | 2022/09/17 18:00 | Yale v Holy Cross | W | 14-38 |
| NCAAF | 2022/09/10 22:00 | Holy Cross v Buffalo | W | 37-31 |
| NCAAF | 2022/09/02 23:00 | Holy Cross v Merrimack | W | 31-17 |
| NCAAF | 2021/12/04 00:00 | Holy Cross v Villanova | L | 16-21 |
| NCAAF | 2021/11/27 17:00 | Sacred Heart v Holy Cross | W | 10-13 |
| NCAAF | 2021/11/20 18:00 | Holy Cross v Bucknell | W | 45-6 |
| NCAAF | 2021/11/13 18:00 | Holy Cross v Fordham | W | 52-24 |
| NCAAF | 2022/09/24 16:30 | Harvard v Brown | W | 35-28 |
| NCAAF | 2022/09/16 23:00 | Merrimack v Harvard | W | 21-28 |
| NCAAF | 2021/11/20 17:00 | Harvard v Yale | W | 34-31 |
| NCAAF | 2021/11/13 17:00 | Pennsylvania v Harvard | W | 7-23 |
| NCAAF | 2021/11/06 17:00 | Harvard v Columbia | W | 49-21 |
| NCAAF | 2021/10/30 16:00 | Dartmouth v Harvard | L | 20-17 |
| NCAAF | 2021/10/23 17:00 | Harvard v Princeton | L | 16-18 |
| NCAAF | 2021/10/16 17:00 | Lafayette v Harvard | W | 3-30 |