Stadion: Meares Stadium Round: 1
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | W | 3-32 |
| NCAAF | 2019/10/19 17:30 | Mars Hill Lions v Limestone Saints | W | 35-28 |
| NCAAF | 2018/09/29 20:00 | Limestone Saints v Mars Hill Lions | W | 41-51 |
| NCAAF | 2022/09/24 18:00 | Barton Bulldogs v Mars Hill Lions | W | 18-24 |
| NCAAF | 2022/09/17 17:00 | Mars Hill Lions v Catawba Indians | W | 38-7 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | L | 44-7 |
| NCAAF | 2021/11/13 20:00 | Wingate Bulldogs v Mars Hill Lions | L | 26-19 |
| NCAAF | 2021/11/06 17:00 | Mars Hill Lions v Tusculum Pioneers | W | 20-7 |
| NCAAF | 2021/10/30 19:00 | Carson–Newman Eagles v Mars Hill Lions | W | 23-49 |
| NCAAF | 2021/10/23 17:00 | Mars Hill Lions v Catawba Indians | W | 31-14 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | W | 3-32 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 27-13 |
| NCAAF | 2022/09/17 17:00 | Carson–Newman Eagles v Limestone Saints | W | 37-40 |
| NCAAF | 2022/09/10 17:00 | St Augustines Falcons v Limestone Saints | W | 14-73 |
| NCAAF | 2022/09/01 23:00 | Gardner Webb v Limestone Saints | L | 56-21 |
| NCAAF | 2021/11/13 21:00 | Limestone Saints v Newberry Wolves | L | 7-42 |
| NCAAF | 2021/11/06 17:00 | Carson–Newman Eagles v Limestone Saints | L | 27-21 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 24-28 |
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | L | 45-3 |