[2] Louisville 21-38 Pittsburgh [12] 2023-10-14 22:30
Stadion: Heinz Field Round: 1
Home Manager: Pat Narduzzi Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2022/10/23 00:00 | Pittsburgh v Louisville | W | 10-24 |
| NCAAF | 2020/09/26 16:00 | Louisville v Pittsburgh | L | 20-23 |
| NCAAF | 2015/11/21 20:45 | Pittsburgh v Louisville | L | 45-34 |
| NCAAF | 2012/10/13 12:00 | Pittsburgh v Louisville | W | 35-45 |
| NCAAF | 2011/11/12 12:00 | Louisville v Pittsburgh | L | 14-21 |
| NCAAF | 2010/10/30 12:00 | Pittsburgh v Louisville | L | 20-3 |
| NCAAF | 2008/11/08 12:00 | Pittsburgh v Louisville | L | 41-7 |
| NCAAF | 2007/10/27 12:00 | Louisville v Pittsburgh | W | 24-17 |
| NCAAF | 2006/11/25 12:00 | Pittsburgh v Louisville | W | 24-48 |
| NCAAF | 2005/11/03 12:00 | Louisville v Pittsburgh | W | 42-20 |